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Latisse: Safety, Side Effects, and What You Need to Know

LATISSE is a prescription medication primarily used to treat hypotrichosis of the upper eyelashes, a condition characterized by inadequate or insufficient eyelashes. It helps to grow eyelashes. The main reason for LATISSE treatment is to address people who have shorter eyelashes and want longer ones. Many people have benefited from LATISSE treatments, which are easy to acquire after a quick consultation for a prescription. While LATISSE offers a solution for those seeking longer, thicker, and darker eyelashes, it's crucial to understand its potential side effects, risks, and necessary precautions. This article provides a comprehensive overview of LATISSE, its mechanism of action, usage, and safety considerations.

What is LATISSE?

LATISSE is approved by the Food and Drug Administration (FDA) to treat hypotrichosis of the upper eyelashes. The active ingredient in LATISSE is bimatoprost ophthalmic solution. Bimatoprost (Latisse) is commonly used to treat hypotrichosis of the eyelashes, which is a condition where there is not enough or few eyelashes. Bimatoprost helps increase eyelash growth in terms of length, thickness, and darkness. The medication is approved after an initial consultation for people who are 18 and older.

Originally, the active ingredient in LATISSE was used in a prescription medication called LUMIGEN, which treats high intraocular pressure (IOP), a potential sign of glaucoma. A side effect of LUMIGEN was eyelash growth, which led to the development of the eyelash-growing serum.

How LATISSE Works

Bimatoprost is part of a group of medicines called prostaglandin analogs. The way it works for eyelash growth is not exactly understood. It is thought to work by increasing the number of eyelash hairs.

Like the hair on top of your head, eyelashes also sprout, grow for a while and eventually fall out. Latisse both extends the growth phase and increases the number of hairs that sprout.

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How to Use LATISSE

Bimatoprost is available as a 0.03% solution that is applied to the skin at the base of the eyelashes.

To use Lumigan® eye drops:

First, wash your hands. Tilt your head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed for 1 to 2 minutes to allow the medicine to be absorbed by the eye.

Remove any excess solution around the eye with a clean tissue, being careful not to touch the eye.

If you think you did not get the drop of medicine into your eye properly, repeat the directions with another drop.

Read also: The Science Behind Latisse

Immediately after using the eye drops, wash your hands to remove any medicine that may be on them. To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye medicines. This medicine comes with patient information insert. Read and follow these instructions carefully. Ask your doctor if you have any questions. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

  • Use bimatoprost at night.
  • Use with the accompanying applicator.
  • Do not apply to the lower eyelid or into the eye. However, if any bimatoprost gets into the eye, you do not need to rinse the eye.
  • To avoid contamination, do not touch the tip of the bottle or applicator, or allow it to come into contact with any surfaces.
  • It may take up to two months to see the benefits of this medicine. However, if you stop using bimatoprost eyelash drops, your eyelash growth will gradually return to the way it was before you started using bimatoprost.

Important Considerations Before Using LATISSE

  • Prescription Requirement: LATISSE requires a prescription from a healthcare provider.
  • Not Always Covered by Insurance: It is unlikely that your health or vision insurance will cover a LATISSE prescription since it does not treat serious eye conditions. Instead, you will pay each month out of pocket for LATISSE while you wait for results to show. There is one condition that may receive coverage from your health insurance: alopecia areata, which causes hair all over the body to fall out in round patches. The condition may impact the eyelids, although this is rare. When it does, eyelashes will fall out.
  • Existing Eye Conditions: The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Certain types of glaucoma (angle-closure, inflammatory, or neovascular)-Not normally used in patients with these conditions. Let your doctor know if you have these conditions. Eye disease (eg, iritis or uveitis), history of-Use with caution. Some eye conditions may be worsened by bimatoprost. Loss of the lens of the eye or a torn lens-Use with caution. May be more prone to a serious side effect called macular edema.
  • Contact Lenses: Bimatoprost can cause discoloration of soft contact lenses. To avoid this, remove contact lenses before using this medicine. You can put them back in at least 15 minutes after you use the medicine.
  • Application Precautions: Bimatoprost may cause hair to grow in areas other than the eyelashes if the medicine comes into repeated contact with the skin surface. Be careful to apply bimatoprost only to the skin of the upper eyelid margin at the eyelash base with the applicators. Blot any excess medicine from the margin, so it does not run onto the cheek or skin.
  • Changes to Iris Pigmentation: Bimatoprost may cause the iris (the colored part of the eye) to increase in brown color. This effect may take months to years to occur and may be permanent, even if you stop using bimatoprost.
  • Eyelid Darkening: Bimatoprost may also cause your eyelid skin to darken, which may return to normal after you stop using bimatoprost.

Common Side Effects of LATISSE

The most common side effects of bimatoprost are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Eye itching
  • Redness in and around the eyes
  • Darkening of the eyelid skin
  • Eye redness and/or itchiness (most common)
  • Dry eyes
  • Eyelid skin darkening

LATISSE® does have some side effects, the most common of which are an itching sensation in the eyes and/or eye redness. These were reported in approximately 4% of patients. Other less common side effects typically occur on the skin close to where LATISSE® is applied, or in the eyes. These include eyelid skin darkening, eye irritation, dryness of the eyes, and redness of the eyelids. Eyelid skin darkening is a result of increased melanin in the skin, making your eyelid skin look a little darker close to where the solution is applied to the skin.

Serious Side Effects of LATISSE

While less common, the most serious side effects of bimatoprost are described below, along with what to do if they happen.

  • Severe Allergic Reactions: Bimatoprost may cause allergic reactions, which can be serious. Stop using bimatoprost and get help right away if you have any of the following symptoms of a serious allergic reaction.
    • Breathing problems or wheezing
    • Racing heart
    • Fever or general ill feeling
    • Swollen lymph nodes
    • Swelling of the face, lips, mouth, tongue, or throat
    • Trouble swallowing or throat tightness
    • Itching, skin rash, or pale red bumps on the skin called hives
    • Nausea or vomiting
    • Dizziness, feeling lightheaded, or fainting
    • Stomach cramps
    • Joint pain
  • Changes to Iris Pigmentation: Changes to iris pigmentation have occurred in people who use LATISSE for a long time. The iris is the part of the eye that determines eye color. In people who have lighter eyes like blue or green, LATISSE may add brown spots that are permanent.
  • Eyelid Pigmentation: LATISSE may also lead to pigmentation changes on the eyelids due to changes in melanin in the skin. Bimatoprost can darken the preorbital area, which is expected to increase with more applications of LATISSE.
  • Macular Edema: Macular edema, or a buildup of fluid in the macula (the center of the retina), has been a reported side effect of LUMIGAN treatment for high intraocular pressure. There is a small risk of macular edema associated with LATISSE because the medication can change fluid pressure in the eye.

LATISSE and Prostaglandins

For eye doctors, the most concerning ingredient in Latisse is its active ingredient, bimatoprost. Bimatoprost is a chemical known as a prostaglandin analogue. Prostaglandins are chemical compounds which are found in naturally in almost all of our body’s tissues, which are responsible for signaling inflammation within the body. As such, it should come as no surprise that Latisse has been associated with common symptoms of inflammation around the eyes, such as:

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  • Swollen lids
  • Redness
  • Itching
  • Watering

In addition to chronic irritation, Latisse has also been known to darken the eyelid skin and the iris color in people with light brown or hazel eyes, as well as potentially causing a “sunken eye” appearance by shrinking the layers of orbital fat around the eye socket.

Why LATISSE May Contribute to Chronic Dry Eye

At first glance, the side effects listed above might seem very minor when compared with other eye issues. However, ocular surface dysfunction and chronic dry eye can take a permanent and lasting toll on your vision quality and comfort. This is because every time we blink, the meibomian glands around our eyes secrete a tiny amount of oil to keep them moist. When prostaglantin analogues cause eye inflammation, the oil thickens, and can no longer spread evenly over the surface of the eye (just like, for example, toothpaste is harder to spread over a surface than olive oil.) The oil can even get so thick that it blocks and backs up in the meibomian glands. If this is not addressed, it can damage the glands permanently. Without any Meibomian glands, the body will not be able to moisten the eye. The result is irreversible and often severe dry eye.

Warnings and Precautions

  • Allergies to Ingredients: People who are allergic to any of the following should not use bimatoprost eyelash drops.
    • Bimatoprost
    • Latisse
    • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in the specific bimatoprost products they stock.

  • Do not use bimatoprost unless it has been prescribed to you by a healthcare provider. Use it as prescribed.
  • Do not share bimatoprost with other people, even if they have the same condition as you. It may harm them.
  • Keep bimatoprost out of the reach of children. If you store it in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.
  • If you develop any type of eye problems or reactions while using bimatoprost, call your healthcare provider right away. This may include problems with the eye or eyelid, such as eye injury, infection, eye swelling and redness, or vision loss.

What to Tell Your Healthcare Provider Before Using Bimatoprost

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if bimatoprost is right for you.

In particular, make sure that you discuss any of the following.

  • Current and past health conditions. Tell your healthcare provider if you have any of the following.
    • Any type of eye problem, including uveitis (inflammatory conditions that affect the middle part of the eye), macular edema, eye pressure problems, no lens (aphakia) or problems with your eye lens
    • Diabetes
    • A history of eye surgery
    • Any medical conditions
  • Other Medicines and Supplements. Bimatoprost may interact with other medicines and supplements. Before using bimatoprost, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
  • Pregnancy. It is not known if or how bimatoprost could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should use bimatoprost while you are pregnant or trying to get pregnant.
  • Breastfeeding. It is not known if bimatoprost passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use bimatoprost while breastfeeding.

Interactions

Does Bimatoprost Interact with Foods or Drinks?

There are no known interactions between bimatoprost eyelash drops and foods or drinks.

It is unknown if drinking alcohol will affect bimatoprost eyelash drops.

Does Bimatoprost Interact with Other Medicines (Drug Interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. In particular, make sure that you discuss if you are using any other prostaglandin analog eye medicine, such as latanoprost (Xalatan, Xelpros, Iyuzeh), bimatoprost (Lumigan, Durysta), or travoprost (Travatan Z, iDose TR), which is a medicine used for high pressure in the eye.

This may not be a complete list of medicines that can interact with bimatoprost eyelash drops. Always check with your healthcare provider. Does interact with other drugs you are taking?

Mixing LATISSE with LUMIGAN

Mixing LATISSE with a similar medication called LUMIGAN can cause unintended side effects. The active ingredient in both medications is bimatoprost ophthalmic solution, which can lower intraocular pressure (IOP).

Alternatives to LATISSE

If you crave longer, darker eyelashes, most optometrists strongly recommend using a high quality mascara, which has the same benefits with much fewer risks. However, if you are determined to use Latisse or a similar eyelash serum product, talk to your eye doctor first about the risks involved. Your eye doctor can monitor you for symptoms of chronic dry eye and other negative side-effects that may permanently damage your tear ducts and ocular surface.

Where to Buy LATISSE

Latisse is a pharmaceutical drug, not a cosmetic, which means you’ll need a prescription from your doctor. Be aware that not every doctor will be familiar with Latisse.

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